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Saffron Vs doluxetine in the treatment of Fibromyalgia: a randomized , double blind controlled trial
This study is a double blind, placebo controlled clinical trial which will be conducted in the clinic of Imam-Khomeini Hospital, Tehran, Iran. 50 patients who meet ACR criteria and inclusion criteria will be recruited. Participants randomly allocated into two groups. Twenty five will receive Duloxetine 30 mg per day during the first week and then 30 mg BID. the other group(25) will receive saffron(15 mg per day in the first week and then 15 mg BID.20 to 40 mg/day and 25 will receive saffron 30 mg/day. Patients were assessed by Breif Pain Index(BPI), Global Fatigue Index and Fibromyalgia Impact Questionnaire (FIQ) at baseline and after 2, 4 6 and 8 weeks after the medication started.
IRCTID: IRCT201604261556N91
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