Study aim: Effectiveness of Repetitive Transcranial Magnetic Stimulation ( rTMS ) add-on therapy to Standard treatment in Multiple sclerosis Patients with Depression Symptoms Design: A controlled clinical trial with parallel groups, phase 2-3 randomized, on 40 patients with multiple sclerosis with depression. Random blocks were used for randomization Settings and conduct: This study is performed in Farshchian Hospital in Hamadan. Due to the fact that patients do not know about the assignment of the group, so a one-way blind study is performed. Patients receive 10-minute direct-current electrical stimulation of the brain with a current of 2 mA, and in the control group receive 10 inactive 20-minute sessions with the same device. Participants/Inclusion and exclusion criteria: Inclusion criteria: Satisfaction to participate in the study,Patient with multiple sclerosis of any type and with moderate and high depression,Not receive repeated trans cranial magnetic stimulation and electroconvulsive therapy in the past two month. Exclusion criteria:Having a shunt and any other metal object near the head Interferon consumption,Pregnant or lactating women,Patients at risk of suicide,Patients with other psychiatric disorders such as bipolar disorder Intervention groups: 20 patients with multiple sclerosis of any type and with moderate to high depression receive direct current electrical stimulation of the brain for 10 sessions of 20 minutes with a current of 2 mA and in the control group receive 10 sessions of inactive 20 minutes with the same device. Main outcome variables: The score of Montgomery-Asberg Depression Inventory, severity of disability and cognitive function in the two groups of intervention and control before the intervention and after the tenth session are compared.