Aim: Evaluating the effect of acupressure in the third liver, four large intestine and placebo points on the PMS symptoms and quality of life in girls with PMS Design of study: randomized, one blinded Population of study: Kowsar dormitory of Hormozgan University of Medical Sciences. Inclusion criteria: Age of 18-45; passing at least two hours after the last meal; having moderate to severe PMS according to the score of premenstrual symptoms screening tool Exclusion criteria: Infectious or skin diseases; acute rheumatoid arthritis; lesion or dermatitis at the site of applying pressure; visual or auditory impairment; avoid taking analgesics for three hours before starting the intervention; severe psychological tension during the last six months (loss of relatives, surgery, etc); heart disease, renal disorder, diabetes, asthma, hypothyroidism or hyperthyroidism, respiratory disorder; genital disease; interval between menstruation lower than 21 or upper than 35 days; PMS in all menstrual cycle Sample size:90 Intervention: Acupressure in the third liver, four large intestine and placebo points Intervention time: Twenty minutes acupressure during 14 days before menstruation for three consecutive menstrual cycles Primary outcome: PMS severity, quality of life