The purpose of this study is evaluation the effect of crocin on inflammatory markers, oxidative damage and DNA damage in the blood of people with multiple sclerosis. Multiple sclerosis is an autoimmune disease in which the immune system attacks the nerve cells that result in nerve demyelination cause neurological disorder. Oxidative stress, free radicals and neuritis have an important role in pathogenesis of the disease. In this study that is done randomly on 40 outpatients in Farshchian hospital of Hamedan.The outpatients devide into 2 groups; the drug group and Placebo group. In the drug group patients will receive two crocin capsules per day for 28 days.The control group will receive two placebo per day, too. After one month of intervention we will measure thiol groups lipid peroxidation, total antioxidant capacity, DNA damage, IL-17, TNF-a in serum of MS patients.