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Objective: Evaluating the effects of Curcuminoids and Vitamin D3 oral supplementation on Glucagon Like Peptide- 1 (GLP- 1) and serum glycemic and lipid profiles, blood pressure and body composition in diabetic type 2 patients; double-blind randomized study; 80 patients will be selected with inclusion and exclusion criteria and will randomly be divided into 4 groups for the 12 weeks of intervention. The first group will receive a Vitamin D3 50,000 IU supplement per week, the second group will receive a supplement that contains 500 milligrams of Curcuminoids per day plus one Vitamin D3 50,000 IU supplement per week, the third group will receive one Curcuminoids supplement daily and The control group will receive a placebo capsule that is similar to Curcuminoids supplements but contains Maltodextrin daily and they also will receive a placebo of Vitamin D3 per week. (each supplement of Curcuminoids contains 500 mg of Turmeric extract that consists of 475 mg Curcuminoids and each capsule of placebo contains 500 mg of Maltodextrin) .
IRCTID: IRCT2017041213678N22
  1. The effect of sodium butyrate and inulin supplementation solo and simultaneously on glycemic index, Txnip gene expression and circulating levels of GLP-1, miR-204, miR-200c and miR-21 in patients with type 2 diabetes
  2. The effects of two training program and vitamin D supplementation on lipid profile, leptin and body composition in obese adolescents with vitamin D deficiency
  3. Effect of vitamin D3 supplementation in people with vitamin D3 deficiency on fasting and 2hpp serum glucose and insulin and improvement of peripheral and visceral adipose tissue
  4. Clinical trial of the effect of vitamin D supplementation compared with the placebo on metabolic profiles in patients with diabetic hemodialysis
  5. Comparision of the effect of vitamin D3 and probiotic containing lactic acid bacteria co-supplementation with vitamin D3 on serum 25(OH)D levels in patients with polycystic ovary syndrome.
  6. The effect of biscuit fortified with whey protein and dietary fiber on biochemical and behavioral factors of appetite, anthropometric indices, and glycemic profile in overweight or obese adults
  7. Effect of oral vitamin D3 supplementation on glycemic parameters, lipid profile, and hs-CRP inflammatory factor in polycystic ovarian syndrome
  8. Effects of vitamin D supplementation on serum levels of adipose tissue browning endocrine regulators, anabolic hormone and exercise performance in male athletes
  9. The effect of synbiotic yogurt consumption on liver echogenicity and markers of liver function in patients with non alcoholic fatty liver disease
  10. Effectiveness of Vitamin D Supplementation in Quality of Life of patient with severe and very severe Chronic Obstructive Pulmonary Disease with serum levels of Vitamin D less than 20ng/ml compared with the control group
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