The aim of this study is to determine the effects of the co-administration of coenzyme Q10 supplement and statins on treatment protocols of ischemic stroke in inflammatory and outcomes level. This is a Quasi experimental study with 30 days follow-up. A total of 60 patients are enrolled in the study, non-randomized dividing into two groups (n=30) including: 1) patients with ischemic stroke, who are only receiving Atorvastatin (40 mg/day) for 30 days. 2) patients with ischemic stroke, who are receiving Atorvastatin and Coenzyme Q10 simultaneously (Q10-300 mg/day) for 30 days. A 5 cc vein blood sample will be taken from patients in admission time, 72 hours and 30 days after ischemia. GFAP protein level will be evaluated by ELIZA method. Both groups will be examined by neurologist in two phases, during admission and after 30 days for neurologic tests (NIHSS, MRS, MMSE).Inclusion criteria: patients with ischemic stroke involving the middle cerebral artery, confirmed by computed tomography scanning and clinical symptoms; range of age 50-70 years; not to receive statins continuously before entering the study; not to receive antioxidants (such as vitamin C and E) constantly; not to receive anti-inflammatory drugs (steroids, nonsteroidal anti-inflammatory) constantly. Exclusion criteria: patient's death during the study; lack of patient`s availability to follow-up; no tendency to attend in next follow-up.