Study aim: The effect of probiotic administration on severity of the menopausal symptoms and mental health of the menopausal women Design: Clinical trial with control group, with parallel groups, triple blind, randomized Settings and conduct: Participants are randomly assigned to the two groups of 45 recipients of Probiotic capsule and placebo group.This study will be conducted in Comprehensive Health Centers of Hamadan city. In this study, neither the researcher, nor the menopausal women and nor the analyzer knows the contents of the package and triple blinded will be performed. In intervention group, Probiotic capsule and in Control group, placebo will be prescribed Once a day for 6 weeks. Participants/Inclusion and exclusion criteria: Inclusion criteria: age between 45-55, having menopause symptoms; not using cigarette or alcohol, not having physical or mental diseases, not using of relaxation techniques, not using of hormonal or herbal therapies Exclusion criteria: irregular use of the drug, refuse from continuing to participate in study Intervention groups: Intervention group: Probiotic supplement will be prescribed in the form of Oral Capsule 200 mg, Once a day for 6 weeks. This drug Will be Producted by Hamadan University of Medical Sciences. Control group: placebo will be prescribed in the form of Oral Capsule contain ُof Starch 200 mg Once a day for 6 weeks. The placebo is made in Hamadan University of Medical Sciences Main outcome variables: Severity of menopause symptoms Stress-anxiety-depression