Study aim: The purpose of this study was to evaluate the effectiveness of treatment based on acceptance and commitment on perceived stress components(perceived tensin and self-efficacy) and emotional adjustment in patients with multiple sclerosis. Design: Clinical trial with experimental and control groups, parallel groups, not-blind, non-random allocation to control and experimental groups; sample size is 40 patients Settings and conduct: Intervention sessions were held during 8 sessions and for 2 months (one session per week) at Sina Hospital in Hamadan Province. Participants/Inclusion and exclusion criteria: Inclusion criteria: Multiple sclerosis according to neurologist diagnosis; willingness and conscious consent to participate in the research project; being literate; Ability to attend meetings; age range between 20 to 50 years old; The duration of the disease ranges from 2 to 5 years. Non-inclusion criteria: severe physical problems. Intervention groups: The research groups consisted of experimental group and control group. The experimental group received admission and commitment-based treatment interventions within two months, but the control group did not receive any intervention. Main outcome variables: Perceived tension; Perceived self-efficacy; Emotional adjustment