Study aim: The aim of this study was to evaluate the effect of 8-weeks of aerobic training at home and vitamin D supplementation on serum levels of BDNF, NGF, fatigue and quality of life in patients with multiple sclerosis during Covid-19 quarantine. Design: For this purpose, 36 women with multiple sclerosis will be randomly divided into 4 groups: aerobic training + vitamin supplementation, aerobic training, vitamin D supplementation and control, as well as vitamin D intake (about 50,000 IU= 1/25 mg per week for eight weeks); Or it will be a placebo. The aerobic training protocol includes 25 to 40 minutes of aerobic exercise with an intensity of 50 to 70% of the maximum heart rate, 3 times a week for eight weeks and online. Settings and conduct: This study was a clinical trial on the effect of 8-weeks of aerobic training at home and vitamin D supplementation on serum levels of BDNF, NGF, fatigue and quality of life in patients with multiple sclerosis during coronary quarantine under the supervision of Razi University of Kermanshah. Pre-test and post-test will be performed. Participants/Inclusion and exclusion criteria: At least 2 years of disease history Expanded Disability Status Scale (3-5) Lack of regular exercise No smoking Do not take immunosuppressive drugs Heart disease High blood pressure Orthopedic disorders Use of other drugs in addition to MS drugs Intervention groups: Aerobic training (placebo); Vitamin D supplementation (no AT); Aerobic training with vitamin D supplements (AT+Vit D); and Control (placebo+no AT) Main outcome variables: Brain-derived neurotrophic factor (BDNF)- Nerve growth factor (NGF)- Fatigue- quality of life