Study aim: Effectiveness comparison of two methods of treatment based on acceptance and commitment therapy (ACT) and relationship enhancement couples therapy (RECT) on intimacy and sexual activity in women with multiple sclerosis in online consulting method Design: A clinical trial with a control group, with parallel groups, without blinding, randomized, on 44 patients, the online random allocation site was used for randomization Settings and conduct: Female patients who are members of MS Association of Shahid Sadoughi Hospital in Yazd, after being divided into two groups of acceptance and commitment therapy and relationship enhancement couples therapy, completed the questionnaire of intimacy and sexual activity of multiple sclerosis then receive 8 online counseling sessions. Participants/Inclusion and exclusion criteria: Entry requirements: Relapsing-remitting type of multiple sclerosis based on the diagnosis of the treating physician, Use online consultation with a smart phone and have an Android or iOS smartphone, Being in reproductive age, Shared bed with spouse, Willingness to participate in the study No entry conditions: Pregnancy, Existence of psychotic disorders and severe mental disorders according to the doctor's diagnosis, Addiction, Existence of domestic violence, Existence of extramarital affair, Existence of emotional divorce according to the research unit Intervention groups: 8 sessions of acceptance and commitment therapy for the intervention group based on online consulting method 8 sessions of relationship enhancement couples therapy for the control group based on online counseling method Main outcome variables: Intimacy and Sexual activity