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Study aim: To compare warmed versus room-temperature intravenous fluid co-loading on spinal anesthesia-induced hypotension in elderly hypertensive patients undergoing orthopedic surgery. Design: Randomized, double-blind, parallel-group clinical trial. Sample size 70 (35 per group). Block randomization with sealed envelopes. Single center. Settings and conduct: Conducting at Al-Karkh Teaching Hospital, Baghdad, Iraq. Elderly hypertensive patients undergoing elective lower limb orthopedic surgery under spinal anesthesia are enrolled after informed consent and randomized to warmed or room-temperature Ringer's lactate co-loading. Standard monitoring includes electrocardiography, pulse oximetry, and non-invasive blood pressure. Participants, anesthesiologist, outcome assessor, and data analyst are blinded; fluids are prepared by a non-blinded nurse and covered with opaque materials. Participants/Inclusion and exclusion criteria: Inclusion: age ≥65, hypertension on medication, ASA II/III, elective lower limb orthopedic surgery under spinal anesthesia. Exclusion: severe hyperkalemia, severe hepatic impairment, lactic acidosis, inability to cooperate. Intervention groups: Group W: Ringer's lactate warmed to 37-38°C. Group R: Ringer's lactate at room temperature (20-24°C). Both co-loaded 10-15 mL/kg over 15-20 minutes after spinal block. Main outcome variables: Primary: incidence of spinal anesthesia-induced hypotension (systolic blood pressure drop ≥20% or <90 mmHg) within 30-45 minutes. Secondary: number of hypotensive episodes, vasopressor requirement, time to first episode.
IRCTID: IRCT20210222050463N10
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  8. Comparison effect of intravascular administration of colloid versus crystalloid in prevention of hypotension after spinal anesthesia for cesarean section
  9. Comparison of the effect of Phenylephrine and Ephedrine in treatment of Spinal Anesthesia induced Hypotension in pregnant women candidate for Cesarean section
  10. Comparison of Phenylephrine and Ephedrine in the treatment of hypotension after spinal anesthesia
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