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Study aim: To examine the effects of J. sambac consumption in combination with a conventional diet on glycemic indices, lipid profiles, inflammatory activity, platelet aggregation and measures of oxidative stress in NAFLD patients. Design: Pragmatic, community bases, parallel group, double blinded, randomised control trial. 90 patients will be enrolled into 3 groups. Study will be done form March-May 2023 Settings and conduct: At Muhammad's physical therapy clinic and rehabilitation center, Multan, Pakistan, 90 suitable persons who had just received a fresh diagnosis of NAFLD (38 men and 52 women) were gathered from outpatient visits Participants/Inclusion and exclusion criteria: Participants in the study were to be 23 to 77 years old, have a body mass index >25 kg/m2, and have diagnosed NAFLD as determined by an ultrasound examination. The following were the exclusion criteria:following a weight reduction diet in the three months earlier, modifying dosage of anti-diabetic, anti-hyperlipidemic, and anti-hypertensive drugs, ingesting just under 70percent of the J. sambacsalad,nicotine, using other drugs, and a past stroke, cardiomyopathy, diabetes, any form of the severe retinal disorder, stomach ulcers, kidney stones, or any additional liver, kidney, lung, or heart disease, among other underlying illness Intervention groups: Before lunch, the 1st group (intervention group) was instructed to eat the conventional diet combined with 200 mg/kg bw/day(12) of J.sambac in the form of salad, while the 2nd group (positive control) received the silymarin with 100mg/kg bw 2 times a day and the 3rd group (negative control) just got the conventional diet. The recommended diet, which included 20% protein, 55% carbohydrate, and 30% fat, supplied around 1500 kcal/day Main outcome variables: Glycemic indices, lipid profiles, inflammatory activity, platelet aggregation and measures of oxidative stress
IRCTID: IRCT20230424057987N1
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