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Study aim: Effect of pre-spinal anesthesia intravenous fluid therapy on the incidence of post-dural puncture headache and hemodynamic disturbances in cesarean section patients Design: • Type: Single-blind randomized controlled trial (RCT) • Groups: Two groups (Intervention vs. Control) • Randomization: Block randomization or random table method • Blinding: Patients are blinded to group assignment. IV fluids are prepared in identical, coded bags. The anesthesiologist and outcome assessors are also blinded to group allocation. Settings and conduct: • Setting: Amir-al-Momenin Hospital, labor ward and operating room • Methods: • Patients are evaluated preoperatively and provide informed consent • Intervention group: receives IV crystalloid [10–15 ml/kg] prior to spinal anesthesia • Control group: receives fluids only as clinically indicated • Outcomes: Hemodynamic parameters recorded in the operating room; post-dural puncture headache assessed at 24, 48 hours, and day 3 postoperatively Participants/Inclusion and exclusion criteria: • Pregnant women scheduled for cesarean section, aged 18–45 years • ASA physical status I–II • Provided informed consent for participation Intervention groups: 1. Intervention group: Receive intravenous crystalloid [10–15 ml/kg] over 15–20 minutes before spinal anesthesia. 2. Control group: No prophylactic preloading; fluids are given only as clinically indicated. Main outcome variables: • Primary outcome: Incidence of PDPH at 24, 48 hours, and day 3 postoperatively, assessed by patient report and VAS (0–10). • Secondary outcome: Hemodynamic disturbances, defined as ≥20% drop in systolic BP or MAP <65 mmHg, and requirement for vasopressors, recorded intraoperatively.
IRCTID: IRCT20240904062951N1
  1. A randomized controlled investigation of crystalloid preloading and co-loading for the avoidance of spinal block-related low blood pressure in parturients undergoing cesarean section
  2. The effects of crystalloid or colloid on maternal blood pressure after spinal anesthesia in cesarean section.
  3. Comparison of aminophylline and paracetamol for the prevention of post-dural puncture headache in women undergoing cesarean section under spinal anesthesia: A randomized controlled trial
  4. Comparison effect of intravascular administration of colloid versus crystalloid in prevention of hypotension after spinal anesthesia for cesarean section
  5. Comparison of two spinal anesthesia approaches: median and paramedian neuraxial blocks on PDPH for cesarean section operations
  6. Comparison of 22‑gauge and 25‑gauge spinal needles on the incidence, severity, and duration of post-dural puncture headache in women undergoing elective cesarean section: A randomized controlled trial in Naseriaeh, Iraq
  7. The comparison of different prophylactic techniques in hypotension due to spinal anesthesia on blood pressure and heart rate of parturients undergoing cesarean section
  8. Effect of Pre-loading of Colloid-Crystaloid Combination on Maternal Hemodynamic Status Following Spinal Anesthesia for Cesarean Delivery
  9. Assessment of Pregabalin Effects on Post-Dural Puncture Headache After Spinal Anesthesia in Elective Cesarean Surgery.
  10. Comparison of post-dural puncture headache after paramedian approach versus Taylor's approach
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