Study aim: Evaluating the Effect of family-centered empowerment on self-care of MS Jahrom patients in 2024-2025 Design: The clinical trial was designed as a randomized, triple-blind, parallel-group study with a control group. Participants were MS patients selected randomly using Random Number Generator software. The selected participants were then allocated to either the intervention or control group through random assignment facilitated by Random Allocation Software. Each group consisted of 31 participants, resulting in a total sample size of 62 individuals. Settings and conduct: With ethics approval and IRCT code, MS patients from Jahrom MS Association were randomly chosen using Random Number Generator software and assigned to intervention or control groups via Random Allocation Software. All signed informed consent. A research assistant administered self-care questionnaires pre- and post-intervention. The control group received family-centered empowerment education post-study. The triple-blind trial kept group assignments hidden from the statistical consultant and data collector. Participants/Inclusion and exclusion criteria: Inclusion Criteria: Confirmed diagnosis of multiple sclerosis by a neurologist. Age between 18 and 50 years. Not in an acute disease phase, with at least 6 weeks since the last relapse. Sufficient ability for self-care. At least 2 years since initial diagnosis. No history of psychiatric disorders or drug addiction. Exclusion Criteria: Acute worsening of condition requiring hospitalization. Death or migration. Intervention groups: Intervention Group: MS patients from the Jahrom MS Association underwent a family-centered empowerment program with four steps: Perceived threat Enhancing self-efficacy Increasing self-esteem via educational participation Evaluation Control Group: Received standard interventions from the MS Association Main outcome variables: self-care