Study aim: Comparison of the effectiveness of doxycycline capsules with and without curcumin capsules in the treatment of patients with acne vulgaris Design: A controlled clinical trial with a parallel group design on 200 patients. Patient allocation will be done using a random draw method. Settings and conduct: Location of this study: Dermatology Clinic, Razi Hospital, Ilam City, Study population: Patients with acne vulgaris, Blinding is not performed in this study. Participants/Inclusion and exclusion criteria: Inclusion criteria: Moderate to severe acne vulgaris and consent to participate in the study. Exclusion criteria: Prescription of topical or systemic medications that could potentially interfere with our treatment course, anti-acne treatment in the past two weeks, symptoms of hyperandrogenism, irregular menstrual cycles, acne fulminans, acne conglobata, liver dysfunction. Intervention groups: The intervention group initially received medications containing 100 mg of doxycycline and labeled A, while the control group received 100 mg of doxycycline + 500 mg of curcumin in a capsule shell and labeled B. Main outcome variables: Facial inflammatory lesions GAGS Global Acne Severity Scoring System