Study aim: Determining the Effect of Mobile-Based Self-Care Education on Fatigue, Symptom Burden, and Self-Management in Patients Undergoing Hemodialysis Design: A randomized controlled clinical trial with parallel groups, single-blind Settings and conduct: Location: Imam Reza 24-Hour Clinic, Shiraz. The data collector and the statistician will be blinded to group assignments. Participants/Inclusion and exclusion criteria: Inclusion Criteria: Minimum literacy skills sufficient to understand the educational content Ability to understand and speak Persian Definitive diagnosis of chronic kidney disease by a nephrologist Age 18 years or older At least 6 months since the initiation of hemodialysis Undergoing hemodialysis three times per week Active access to a smartphone and the Internet, with the ability to use social media Not participating concurrently in other hemodialysis-related educational programs Exclusion Criteria: Presence of a chronic psychiatric disorder diagnosed by a physician Acute myocardial infarction and being on mechanical ventilation at the time of the study Undergoing kidney transplantation Lack of willingness to continue participation in the study Failure to attend three consecutive sessions of the provided educational content Intervention groups: The intervention in the experimental group will consist of mobile-based self-care education. This education is structured according to the Self-Care Matrix theory across four main domains: activities, behaviors, context, and environment. In the first session, instructions on how to participate in the program will be provided through audio messages and video clips shared in the selected social media group. Control Group: Participants in this group will not receive any of the interventions provided to the experimental group. Main outcome variables: Fatigue, Symptom Burden, and Self-Management