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Study aim: *A) General Objective: To determine the efficacy of a combination product based on Chasteberry (Vitex agnus-castus*) compared to Dydrogesterone on oligomenorrhea caused by Polycystic Ovary Syndrome (PCOS) Design: Patients will be randomly assigned to two groups (control and intervention) using block randomization in blocks of four. Randomization will be performed using a random allocation list generated by Excel. The study will be conducted in a triple-blind manner (blinding the patient, the primary investigator, and the statistical analyst). To ensure blinding, Dydrogesterone and the herbal medication will be randomly assigned codes A and B; these codes will only be revealed after the statistical analysis is completed to prevent performance and information bias. The control group will receive 10 mg of Dydrogesterone, while the intervention group will receive a herbal capsule formulated from Chasteberry (including Vitex agnus-castus* seeds, Daucus carota seeds, and Mentha pulegium leaves). Furthermore, Dr. Samira Eghbali, a faculty member at the School of Pharmacy, Birjand University of Medical Sciences, is designated to handle the coding of medications and patients to maintain the triple-blind integrity of the study Settings and conduct: Gynecology clinics at Valiasr Hospital and Rouyesh Infertility Center, Birjand, during 2026-2027. Participants/Inclusion and exclusion criteria: Women18-45age with pco Intervention groups: chemical drog and herbal drog Main outcome variables: Incidence of menstrual bleeding and regularization of cycles.
IRCTID: IRCT20251224068427N1
  1. The effect of cream containing vitex agnus castus extract and foeniculum vulgare essential oil on mild and moderate hirsutism symptoms
  2. The effect of Vitex agnus-castus and Flaxseed on duration and severity of breast pain in women with cyclical mastalgia: A randomised controlled trial
  3. Comparison of the effect of portulaca oleracea L. and foeniculum vulgare mill and vitex agnus castus L. with spironolactone and cyproterone compound on hirsutism on patient with polycystic ovary syndrome
  4. Evaluating the effect of vitex agnus castus on treatment of premenstrual syndrome among students of Tehran University of Medical Sciences and Tehran University
  5. Comparison of Panjangosht (Vitex agnus-castus) and Maryamgoli (Salvia officinalis) effects on the serum lipids and Sexual Function in menopausal women
  6. On the consideration and comparison of Panjangosht (Vitex agnus-castus) and Maryamgoli (Salvia officinalis) effects on the osteogenic factors and physical and emotional symptoms in menopausal women
  7. Comparing Effect Of Mefenamic Acid And Vitex Agnus Castus On IUD- Iinduced Bleeding
  8. comparative study of the effect of capsule containing Vitex agnus castus extract with nigella sativa powder in comparison with citalopram in reducing hot flashes in postmenopausal women
  9. The Combined Effect of black cohosh, soybean, arctium lappa L and vitex agnus- castus extracts on clinical symptoms, biomarkers of oxidative stress biomarkers and inflammation among menopausal women
  10. The effect of tablet contain mixture of extract of Vitex agnus castus, Chamomile, Echium amoenum and vitamin B6 on symptoms of Premenstrual Syndrom (PMS)
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