Study aim: Comparing the effects of strength-oriented and endurance-oriented resistance training on clinical outcomes in patients with diabetic neuropathy Design: A randomized clinical trial with two parallel groups. A total of 34 participants will be randomly allocated to either the strength resistance training group or the muscular endurance resistance training group using Research Randomizer software. Settings and conduct: This trial compares strength- and endurance-oriented resistance training in patients with diabetic neuropathy at the Sports Medicine Clinic, Loghman Hakim Hospital, during 2026–2027. Participants and trainers cannot be blinded due to the intervention; outcome assessors and the statistician will be blinded to allocation, and groups will be coded for analysis. Participants/Inclusion and exclusion criteria: Inclusion criteria: Diagnosis of diabetes with diabetic neuropathy, medical eligibility for resistance training, and provision of informed consent. Exclusion criteria: Presence of autonomic neuropathy; Presence of non diabetic neuropathy; Current tobacco use; Diagnosis of rheumatoid arthritis; History of surgery within the past month Intervention groups: Intervention Group 1 (Resistance Strength Training): Twice-weekly training for 8 weeks, starting at 50% of one-repetition maximum (1RM), with 8–12 repetitions per set, progressively increasing to 90% of 1RM according to individual tolerance.Intervention Group 2 (Resistance Endurance Training): Twice-weekly training for 8 weeks, starting at 30% of 1RM, with 12–20 repetitions per set, progressively increasing to 40% of 1RM according to individual tolerance. Main outcome variables: One-Repetition Maximum (1RM); Michigan score (MNSI)