The effect of concurrent curcumin and vitamin D supplementation on headache symptoms and calcitonin gene-related peptide level (CGRP) in patients with migraine

The effect of concurrent curcumin and vitamin D supplementation on headache symptoms and calcitonin gene-related peptide level (CGRP) in patients with migraine

Randomized clinical trial

Migraine patients who refer to clinics affiliated to Shahrekord University of Medical Sciences are treated with curcumin and vitamin D supplements.

1.Willingness to cooperate with the plan ۲. Diagnosis of migraine by a neurologist based on ICHD-3 criteria. 3. Age 20 to 50 years. 4. No chronic diseases 5. Absence during pregnancy and lactation .. Taking dietary supplements or medication (nutritional supplements, multivitamin mineral and W3 supplements or anti-migraine medications (valproate, amitriptyline, etc.), anti-inflammatory and anti-depressant pills, Aspirin and NSAIDs, contraceptives in the last three months 6. No alcohol and smoking Exclusion criteria: 1. Failure to follow the recommendations and diet. ۲. Failure to refer the person at different stages of the study. 3. Cardiovascular disease, hypertension, diabetes, liver, kidney, thyroid, malignancies and other neurological disorders. 4. Taking nutritional and herbal supplements that affect migraines

"Intervention group": migraine patients intake curcumin supplement in the form of 500 mg capsules, one per day with routine treatment(Two 200 mg sodium valproate tablets and two 20 mg propranolol tablets) and a soft oral vitamin D capsule with a dose of 2000 international units daily. "Control group": migraine patients intake placebo of curcumin and vitamin D supplement one per day with routine treatment (Two 200 mg sodium valproate tablets and two 20 mg propranolol tablets).

Migraine severity, migraine frequency, duration of migraine headache, Calcitonin gene-related peptide

Eligible subject be selected with convenience sampling and be randomly assigned into 2 groups of 25 subjects as treatment and control with block sizes of 3 and 6 with proportion 1:1. A person from research team not involved in the recruitment and assigning participants generate allocation sequence using web site of www.Randomization.com.

After explaining the purpose of the study, all participants and investigators are blinded to random allocation. Participants in vitamin D group receive vitamin D 1000 IU supplement and curcumin capsules while control group take placebo with the same size and color as vitamin D(Oral paraffin) soft gels and curcumin.