Comparison of the effect of Propolis and chlorhexidine mouthwashes on some complications of impacted mandibular Third molar extraction surgery

Comparison of the effect of propolis mouthwash and 0.02 chlorhexidine on the complications of mandibular impacted third molar surgery.

Phase 3 clinical trial, with cross-over groups, sample size of 20 people, randomized by throwing dice, double-blind

The current study is a split mouth clinical trial study, which will be conducted in order to investigate the effect of propolis mouthwash intervention on complications caused by mandibular impacted third molar surgery. All participants will be explained about the intervention, its goals, possible side effects and effects, participants, service providers and people who will perform the data analysis will be blinded to the type of grouping and receiving the type of intervention.

Inclusion criteria: Above 18 years old Healthy people (ASA I or II) (healthy people, a person who has a mild systemic disease and the disease is under control and has not caused any restrictions to the patient) People who need bilateral mandibular impacted third molar surgery (with impact grade one and A based on the Pelland Gregory standard) Not taking antibiotics for at least 2 weeks Absence of any inflammation and acute infection in the surgical area Absence of pregnancy and breastfeeding Absence of smoking and tobacco addiction Not allergic to honey Exclusion criteria: Lack of cooperation and adherence to protocols Smoking and tobacco use

Consumption of propolis mouthwash and 0.02 chlorhexidine mouthwash as two intervention groups for one week, twice a day after breakfast and before bed for 30 seconds.

Swelling rate; pain level; Mouth opening rate

In this study, the allocation of participants will be done based on the randomization method and by using dice. After selecting people according to the calculated sample size, numbers 1, 3, and 5 are considered for group A and numbers 2, 4, and 6 for group B

In order to make the study blind, 40 similar containers were prepared by the first colleague, and A label and B label will be transferred to the containers, and without the knowledge of the second colleague, the contents of each label will be delivered to him, and after the completion of the first surgical procedure, the patients will be The second colleague is randomly divided into two groups, A and B, and the mouthwash of the same group is delivered to the patient, then after three weeks of the first surgery, the patient comes for the second surgery of the impacted tooth on the opposite side, and this time the second mouthwash, which is different It is given with the first one.

The participants’ data, including age, gender, pre- and post-study results, will be disclosed at the conclusion of the study at the discretion of the project manager.

Access to the data in question will commence one year after the publication of the results.

Researchers, professors, and students with an official document from a research institute, university, industrial, or pharmaceutical centers.

The data will be accessible to offer guidance on conducting a study or designing similar studies, and there is also the option to undertake meta-analysis studies in collaboration with the project manager; under no other circumstances is the utilization of the data permitted.

Applicants can correspond with Dr. Meysam Bigdelou, as the project manager, to receive data.

Issuing certificates from research, academic, and industrial institutions endorsed by that center to meet data requirements and providing a clear explanation of their objectives concerning the data and how the data will be utilized.