We have evaluated the effects of massage therapy on infants' response to phototherapy that were under treatment of hyperbilirubinemia. Enrolled infants were randomly divided into 2 groups: phototherapy alone (control/ no intervention group) and phototherapy + massage (case/ intervention group). The first baby referred was randomly determined to be enrolled in the control group, and the next infant was included in the case group. This process was repeated for each infant enrolled. Two phototherapy devices were randomly used in the case and control groups. Infants in the control group received traditional phototherapy and intensive care. Infants in the intervention group received massage in addition to conventional phototherapy and intensive care. Massage was performed thrice daily (every 8 h) for 30 min each. Before the massage, the hands of the researcher were warmed to the body temperature of the infant. Using gentle pressure, the researcher usually massaged different parts of the body with the soft parts of the fingers of both hands. Six organs of the body were massaged)lower limbs, upper limbs, abdomen, chest, back, and head and neck(.Patient data, including sex, birth weight, symptoms at presentation, duration of hospitalization, and treatment, were recorded by the pediatric resident or neonatal specialty doctor for each patient. A thorough examination of the newborn was done. Laboratory tests to determine the cause and severity of jaundice included to measure hematocrit, complete blood count, direct and indirect bilirubin, direct and indirect Coombs test, reticulocyte count, infant and maternal blood groups and Rh type).