Comparison of Hyaluronic Acid injection with and without corticosteroids on the severity of pain and physical function in patients with knee Osteoarthritis grade 2 and 3

To investigate changes in bone pain intensity, improvement in physical function due to knee osteoarthritis after treatment compared to before treatment in recipients of hyaluronic acid alone compared to recipients of corticosteroids + hyaluronic acid.

A clinical trial with a control and intervention group, double-blind, on 88 patients, randomization with a sealed envelope.

Participants at Imam Hossein Hospital will be randomly assigned to 2 groups: 1) hyaluronic acid injection alone and 2) hyaluronic acid and corticosteroid combination injection. After patient preparation and local anesthesia, the injection will be performed by a pain specialist using an inferomedial method under ultrasound guidance, with an 18-gauge green needle in the knee joint.

Inclusion: Patients with grade 2 and 3 knee osteoarthritis who are candidates for therapeutic interventions for pain control and referred to the pain clinic of Imam Hossein Hospital. Exclusion: Patients with bone malignancies, drug addicts, history of allergy to hyaluronic acid or corticosteroid drugs, patient dissatisfaction

Control group 1: Injection of 40 mg of hyaluronic acid alone in the knee joint from the brand Rodiyax-C Target intervention group: Injection of 44 mg of hyaluronic acid and 9 mg of triamcinolone in the knee joint from the brand Rodiyax -T

Pain measurement with VAS and physical dysfunction with The Western Ontario and McMaster Universities Osteoarthritis Index

Permuted Randomized Blocks :In this method, 10 random blocks are generated by computer Software R. Each block includes 5 people in the intervention group and 5 people in the control group. The order of these people is randomly arranged by computer and people are assigned to groups in the same way. At the end of each block, a new block of 10 is produced and this process will continue until the final sample volume is reached.

Forms with numbers 1 and 2 inside the packaged envelopes are used to group patients, which are given to patients randomly and the patients are not aware of the groupings. Before the injection begins, the envelope is opened by the anesthesiologist in charge of the patient and given to the patient based on the intervention or control group that was prepared in advance. The clinical caregiver, the evaluator and the results recorder, and the participant are not aware of the grouping.