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Women who refer to the clinic with the complaint of early menopause symptoms will be examined after giving consent to participating in research, and if they have inclusion criteria but not any exclusion criteria. In this study, we will use the convenient sampling and then the participants will be classified into 3 groups in the basis of random numbers. These groups are Fenugreek group, hormone therapy and placebo group. In Fenugreek extract group, two capsules each containing 500 mg extract of Fenugreek, equivalent to 6 grams of Fenugreek seeds, will be used daily (1 g total per day), after consultation with the pharmacologist and similar to analogous studies. In Hormone therapy group, two capsules containing 0/625 mg of conjugated estrogen and 2/5 mg of medroxy progesterone acetate powder will be used daily, and in the placebo group, two capsules containing lactose will be consumed daily. The duration of treatment will be 2 months. In this study, in order to evaluate the effect of the drug, climacteric Green questionnaire (Green's critical scale) will be used. In summary, before starting the study, every subject will complete two questionnaires: background variables questionnaire and Green questionnaire, and then in the fourth week and also in the eighth week after the intervention, Green questionnaire will be completed. finally, the groups’ scores, after and before treatment, will be compared together.
IRCTID: IRCT138811283348N1
  1. Comparison of the efficacy of oral Trigonella foenum-graecum seed extract and oral azithromycin in the severity of acne vulgaris; a randomized controlled clinical trial
  2. Comparison of fenufreek extract vaginal cream with ultra low dose conjugated estrogen vaginal cream on atrophic vaginitis among menopausal women.
  3. Comparative effects of conventional hormone replacement therapy and tibolone on climacteric symptoms and sexual dysfunction in postmenopausal women
  4. Study of the slow release fenugreek (Trigonella foenum-graecum ) seed formulation on pain relief in patients with temporomandibular disorder
  5. Effect of green basil (Ocimum basilicum) leaf powder versus placebo on menopausal rating scale and sleep quality in postmenopausal women: a triple-blind randomized clinical trial
  6. Comparing the effects of Akkermansia muciniphilia postbiotic , Lactobacillus rhamnosus postbiotic and green tea extract on body composition, anthropometric and biochemical indices, appetite, and depression scores in overweight or obese adults: a Randomized, double-blind, controlled clinical trial
  7. Effectiveness of Ointment Containing Hops Nanoparticles for Relieving Early Menopausal Symptoms
  8. Effects of Tibolone on cardiovascular disease in menopausal women
  9. The effects of conjugated linoleic acid supplementation on, maximum oxigen consumption, resistance exercise, body composition and blood pressure in men.
  10. Comparison of the effect of metanolic green tea، green coffee extract and chlorhexidine and on the salivary Streptococcus mutans ُin preschool children with early childhood caries by the PCR
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