Objective: To determine the effect of spiritual/religious training intervention on anxiety of individuals scheduled for Coronary Artery Bypass Graft surgery. Inclusion criteria include: candidate for coronary artery bypass graft surgery, Muslim Shia, age between 45-75 years old, first time hospitalized for coronary surgery, without diagnosed mental disorder. Study population include all of coronary artery bypass graft’s candidates that hospitalised in Tehran’s Shahid Lavasani hospital for April to July 2011. Participants were 66 patients with ischemic heart disease who selected from study population based on inclusion criteria and randomly allocated in two control and intervention groups. Interventions consisted of five sessions of Spiritual-religious training based on Richards and Bergin’s technique in five days. Each session continued for 45 to 60 minutes. Anxiety measured before, and 2 hours after intervention before surgery. Rate of anxiety compared before and after intervention in intervention and control groups.