Study aim: Comparing the effect of capsule containing Akkermansia muciniphila postbiotic Lactobacillus rhamnosus postbiotic and green tea extracts on body composition, anthropometric and biochemical indices in obese and overweight adults Design: This study is a randomized, double- blinded, phase 3 controlled clinical trial with four parallel groups (3 intervention and one control groups). 108 individuals (27 in each group) were randomized into groups with balanced- blocked randomization. Settings and conduct: 108 eligible individuals referred to Imam Reza clinic, after becoming informed and obtaining informed consent, are randomly assigned into 4 study groups. They receive group samples, which are named the same as the groups with the letters A, B, C and D to blind the participant and the researcher and they take it daily before meals for 12 weeks. Body composition, anthropometric and biochemical indices and appetite and depression scores will be assessed before and after the study Participants/Inclusion and exclusion criteria: Inclusion criteria: • Overweight or obese age 20 to 50 years • Not being menopause for females •Not suffering from metabolic, endocrine, chronic diseases or any kind of infection •Not hospitalized, did not use antibiotics, probiotic or prebiotic supplements or any medication for 3 months before the study Exclusion criteria: • Pregnancy and lactation Intervention groups: The study groups, including intervention and control groups, included the first group, which included postbiotic Akkremancia muciniphila and green tea extract, the second group, which included postbiotic Lactobacillus rhamnosus and green tea extract, the third group, which included postbiotics and green tea , and the fourth group, which included the control group. The control group was used capsules containing fillers such as Avicel or croscarmellose. Main outcome variables: Body weight, WC, BMI