Study aim: This study aims to compare demographic, clinical and nutritional characteristics of patients with Parkinson’s disease and to evaluate the effects of ginger supplementation on Antioxidant and oxidant Markers, Clinical Outcome, quality of life and body mass index compared with placebo. Design: This is a randomized, double blind, parallel, placebo controlled clinical trial using stratified balanced block randomization. Settings and conduct: A total of 48 patients will be recruited from the Isfahan Parkinson Charity Association. After a two week run in period, the intervention group will receive 1000 milligrams of ginger powder daily and the control group will receive placebo for 12 weeks. Participants/Inclusion and exclusion criteria: Patients aged 50 to 80 years with Parkinson’s disease, body mass index above 18.5 and stable medication will be included. Exclusion criteria include special diets, recent ginger or antioxidant supplement intake, thyroid disorders, severe psychiatric or cognitive disorders, smoking, alcohol use, anticoagulant, anti inflammatory, immunosuppressive drugs or insulin use. Intervention groups: Participants will be randomly allocated to ginger or placebo groups. Main outcome variables: Serum levels of Superoxide dismutase, Glutathione peroxidase, total antioxidant capacity, total oxidant status, Parkinson’s disease severity using the Movement Disorder Society Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale, quality of life, body mass index, energy and nutrient intake and physical activity will be assessed.