In this study, the random permutation block method will be used for randomization. For this purpose, a block of 6 will be used. In each block, three cards will be written with the letter I (Intervention) and three cards with the letter P (Placebo). To hide the cards, they will be placed in an envelope and turned over several times so that their order is not clear. As each participant enters, a card will be selected for him and the selected card will be set aside. This will be done for the next five patients until 6 people are identified. Then, randomization will be done in the same way for the other groups of 6 people to achieve the desired sample size.
Some of the selected random blocks of 6 are as follows:
PIPIIP, PPIPII, IPPIIP, PIPIPI, IPPIIP, IPIIPP, PIIIPP, IPPIIP, PIIPPI, PPIPII, LPLLPP, LLPLPP, IPPIIP (For example, the random assignment in the 6-patient block PIPIIP is as follows: the first patient is randomly assigned to treatment P, the second patient is randomly assigned to treatment I, the third patient is randomly assigned to treatment P, the fourth patient is randomly assigned to treatment I, the fifth patient is randomly assigned to treatment I, and the sixth patient is randomly assigned to treatment P.)